No adverse effects on human health as a functional sweetener (Functional Sweeteners) Neotame play a useful role in regulation or promote. Apply as early as the neotame December 1998 as a food sweetener low temperature in the United States. On July 9, 2002 audit by the U.S. FDA food additives allow the application in all food and drink. 2003 No. 4 Notice of the Ministry of Health of the People's Republic of China also formally approved Neotame for new food additives, suitable for various types of food production.